VSL#3 can prevent ulcerative colitis-associated carcinogenesis in mice

Figure 1 Experimental protocol for ulcerative colitis-associated carcinogenesis model and treatment.

Figure 2 Body weight in each group.

Figure 3 Representative image of colonic tumor in each group that was examined under naked eye.

Figure 4 Representative image of hematoxylin-eosin staining of colon tissue examined under a microscope (40 × and 100 ×). A: Control group, the colonic mucosa glands were normal in the control group, the structure was regular, and the opening was good; B: Model group, the colonic gland structure presented disorder, large nuclei, deep staining, and nucleoplasmic ratio imbalance.

Figure 5 Tumor load in each group. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.

Figure 6 Colonic tumor necrosis factor-α and interleukin-6 levels in different groups. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. TNF-α: Tumor necrosis factor-α; IL-6: Interleukin-6.