Liposarcoma of the stomach: Report of two cases and review of the literature

Figure 1 Histological finding. Low magnification shows that the immature fat cells are interspersed among smooth muscle tissues (A: HE, × 40 and B: HE; × 100). The large nuclear dark-stained lipoblast, which appears as a mononuclear or multinucleated cell with one or more cytoplasmic vacuoles, are seen under high magnification (C; HE; × 200 and D: HE; × 400).

Figure 2 Fluorescence in situ hybridization detection shows amplification of MDM2 gene (A and B), case 1.

Figure 3 A limited knurl was distributed from lower part of the gastric body to the corner of the stomach (A), and a knurl was also found in the gastric fundus (B).

Figure 4 Endoscopic ultrasound examination located the tumor mainly in the submucosa of the gastric wall.

Figure 5 Process of the endoscopic submucosal dissection.

Figure 6 Gross specimen of the tumor.

Figure 7 Histological findings. Under low magnification, irregular cell cluster nests were seen around the mature adipocytes (A: HE; × 20 and B: HE; × 40); intermediate magnification and high magnification showed that the heteromorphic cell nests consisted of large nuclear dark-stained tumor cells, with distinct cell shapes, irregular cell morphologies, and visible Mitosis icon (C: HE; × 100, D: HE; × 100, E: HE; × 200, and F: HE; × 400).

Figure 8 Fluorescence in situ hybridization detection shows MDM2 gene amplification, case 2.