Prognostic value of perioperative leukocyte count in resectable gastric cancer

Figure 1 Kaplan-Meier curves depicting overall survival. A: Patients with higher preoperative white blood cell count (WBC) had shorter overall survival (OS) when divided by the median; B: Patients affected by p-leukopenia had worse OS; C: Patients whose WBC < 4.0 × 10⁹/L after surgery had lower OS than those whose WBC ≥ 4.0 × 10⁹/L; D: Combined analysis of OS by pre- and postoperative WBC. Patients with low preoperative WBC but without p-leukopenia showed the optimal OS, significantly longer than that in patients who had both high preoperative WBC and p-leukopenia.

Figure 2 Neutrophil count (A, B), lymphocyte count (C, D), and neutrophil to lymphocyte ratio (E, F) in patients with and without p-leukopenia or postoperative leukopenia before and after surgery. P-leukopenia refers to preoperative WBC ≥ 4.0 × 10⁹/L and postoperative WBC < 4.0 × 10⁹/L, with an absolute decrease ≥ 0.5 × 10⁹/L WBC. Postoperative leukopenia (Post leukopenia) here was defined as WBC < 4.0 × 10⁹/L. Data was presented as mean ± SD. P values were determined by Student’s t test compared with the corresponding values before operation. WBC: White blood cell.