Management of acute pancreatitis in Japan: Analysis of nationwide epidemiological survey

Figure 1 Mortality of the acute pancreatitis patients with the prognostic factor scores and computed tomography grades. A: Mortality of the 1990 AP patients stratified by the prognostic factor scores is shown. B: Mortality of the 1618 AP patients stratified by the CT grades is shown. AP: Acute pancreatitis; CT: Computed tomography.

Figure 2 Mortality was higher if any of the prognostic factor items were positive. The mortality of the AP patients was assessed in the presence or absence of each prognostic factor items. ^bP < 0.01 (χ² test). AP: Acute pancreatitis; BE: Base excess; BUN: Blood urea nitrogen; SIRS: Systemic inflammatory response syndrome; LDH: Lactate dehydrogenase.

Figure 3 Receiver-operating characteristics curve analysis of the prognostic factor items. ROC curve analysis of the 9 (A) or 4 (B) prognostic factor items. AUC for predicting mortality was 0.84 for the 9 prognostic factor items and 0.82 for the 4 prognostic factors (base excess or shock, renal failure, SIRS criteria and age) and was found to be associated with AP-related death by a multivariate analysis. SIRS: Systemic inflammatory response syndrome; ROC: Receiver-operating characteristics curve; AUC: Area under the curve; AP: Acute pancreatitis.

Figure 4 Temporal changes in mortality of patients with walled-off necrosis. Mortality of the patients with WON in the 2003, 2007, and 2011 surveys is shown. ^bP < 0.01 (χ² test). NS: Not significant; WON: Walled-off necrosis.

Figure 5 Flow-chart of treatment strategy for walled-off necrosis in the patients in the 2011 (A) and 2007 (B) surveys. A: The treatment strategy for the 40 patients who required intervention for WON in the 2011 survey is shown. B: The treatment strategy for the 15 patients who required intervention for WON in the 2007 survey is shown. WON: Walled-off necrosis.

Figure 6 Flow-chart of treatment strategy for walled-off necrosis in the acute pancreatitis patients in the 2003 survey. The treatment strategy for the 25 patients who required intervention for WON in the 2003 survey is shown. AP: Acute pancreatitis WON: Walled-off necrosis.

Figure 7 Temporal changes in mortality of patients with walled-off necrosis who received intervention. Mortality of the patients with WON in the 2003, 2007, and 2011 surveys is shown. ^aP < 0.05 (χ² test). NS: Not significant; WON: Walled-off necrosis.