Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis

Figure 1 Body weight and organ indices in rats. A: Body weight; B: Liver index. ^bP < 0.01 vs N group at 4 wk; ^dP < 0.01 vs N group at 6 wk; ^fP < 0.01 vs M group at 6 wk; ^hP < 0.01 vs N group at 8 wk; ^jP < 0.01 vs M group at 8 wk.

Figure 2 Histopathological changes of hepatic tissues as revealed by HE staining (n = 6, × 200). A: N; B: M at 4 wk; C: MA at 4 wk; D: M at 6 wk; E: MA at 6 wk; F: M at 8 wk; G: MA at 8 wk.

Figure 3 Histopathological changes of hepatic tissues as revealed by Masson’ trichrome staining (n = 6, × 200). A: N; B: M at 4 wk; C: MA at 4 wk; D: M at 6 wk; E: MA at 6 wk; F: M at 8 wk; G: MA at 8 wk.

Figure 4 Histopathological change of small intestinal mucosa as revealed by HE staining (n = 6, × 200). A: N; B: M at 4 wk; C: M at 6 wk; D: M at 8 wk; E: MA at 4 wk; F: MA at 6 wk; G: MA at 6 wk.

Figure 5 Levels of TNF-α and IL-6 in the tissue homogenates of liver and ileum (n = 6). A: The levels of TNF-α; B: The levels of IL-6. ^aP < 0.05, ^bP < 0.01 vs N group; ^cP < 0.05 vs M group.