Anticancer effect of adenosine on gastric cancer via diverse signaling pathways

doi:10.3748/wjg.v21.i39.10931

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2015; 21(39): 10931-10935
Published online Oct 21, 2015. doi: 10.3748/wjg.v21.i39.10931

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Figure 1 Adenosine receptors and their relevant signaling pathways. A₁: A₁ adenosine receptor; A_2a: A_2a adenosine receptor; A_2b: A_2b adenosine receptor; A₃: A₃ adenosine receptor; PLC: Phospholipase C; IP3: Inositol 1,4,5-trisphosphate; DG: Diacylglycerol; PKA: Protein kinase A; PKC; Protein kinase C.

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Figure 2 Intracellularly transported adenosine and the ensuing signaling pathways. AMPK: AMP-activated protein kinase; ADP: Adenosine diphosphate; ATP: Adenosine triphosphate.

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Figure 3 Extracellular adenosine-induced apoptosis of gastric cancer cells. A: The adenosine-induced apoptotic pathway for GT3-TKB and HGC-27 cells; B: The adenosine-induced apoptotic pathway for MKN28 and MKN45 cells. AMPK: AMP-activated protein kinase.

Citation: Tsuchiya A, Nishizaki T. Anticancer effect of adenosine on gastric cancer via diverse signaling pathways. World J Gastroenterol 2015; 21(39): 10931-10935
URL: https://www.wjgnet.com/1007-9327/full/v21/i39/10931.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i39.10931