Meta-Analysis
Copyright ©The Author(s) 2015.
World J Gastroenterol. Jul 28, 2015; 21(28): 8687-8696
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8687
Figure 1
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Figure 1 No and high expression of human epidermal growth factor receptor protein in colorectal cancer. A: No expression of HER-2 protein in normal mucosa samples, as detected with IHC (× 100); B: High expression of HER-2 protein in colorectal cancer tissue samples, which immunohistochemistry showed were positive (× 100). HER-2: Human epidermal growth factor receptor.
Figure 2
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Figure 2 Expression rate of human epidermal growth factor receptor protein in colorectal cancer. A: The expression of HER-2 protein in moderately differentiated, weakly positive colorectal cancer tissue (IHC+, × 100); B: The expression of HER-2 protein in moderately differentiated, positive colorectal cancer tissue (IHC++, × 100); C: The expression of HER-2 protein in moderately differentiated, strongly positive colorectal cancer tissue (IHC+++, × 100). HER-2: Human epidermal growth factor receptor.
Figure 3
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Figure 3 Three and five-year overall survival in colorectal cancer patients. A: Plot of 3-year overall survival in HER-2-positive and HER-2-negative colorectal cancer patients; B: Plot of 5-year overall survival in HER-2-positive and HER-2-negative colorectal cancer patients. HER-2: Human epidermal growth factor receptor.
Figure 4
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Figure 4 Three and five-year disease-free survival in colorectal cancer patients. A: Plot of 3-year disease-free survival in HER-2-positive and HER-2-negative colorectal cancer patients; B: Plot of 5-year disease-free survival in HER-2-positive and HER-2-negative colorectal cancer patients. HER-2: Human epidermal growth factor receptor.
Figure 5
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Figure 5 Forest plot of the expression of human epidermal growth factor receptor protein in colorectal cancer patients and in healthy controls. HER-2: Human epidermal growth factor receptor.
Figure 6
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Figure 6 Forest plot of the expression of human epidermal growth factor receptor protein in overall survival and disease-free survival. A: 3 year overall survival rate; B: 5 year overall survival rate; C: 3 year disease free survival rate; D: 5 year disease free survival rate. HER-2: Human epidermal growth factor receptor.