In vivo gastric mucosal histopathology using endocytoscopy

Figure 1 Single charged-couple device integrated type endocytoscope (GIF-Y0002, a prototype from Olympus, Tokyo, Japan).

Figure 2 Normal pit-dominant type in the gastric corpus. A regular arrangement of gastric pits is observed, with true capillary network.

Figure 3 Normal papilla-dominant type in the gastric antrum (A) and the rounded papillae are tightly-packed and regularly arranged, surrounding coiled capillaries (B).

Figure 4 Irregular endocytoscopic patterns. A: Unclear surface epithelium with necrotic tissue; B: Gastric pits (forming sulcus) are visualized when open and more easily stained; C: Completely stained epithelium, with goblet cells.

Figure 5 Histopathology of normal fundus gland and normal antral gland. A: Histopathology showing the arrangement of normal fundus gland in the corpus. The arrangement of the surface mucosal epithelium is regular, with little inflammation; B: Histopathology showing the arrangement of normal antral gland. There is no inflammation and the arrangement of the surface mucosal epithelium is regular.