Resveratrol and genistein inhibition of rat isolated gastrointestinal contractions and related mechanisms

Figure 1 Gastrointestinal contractile activity. Sample traces showing contractile activity in body of stomach (A); duodenum (B); and antrum of stomach (C). Gen: Genistein; Res: Resveratrol.

Figure 2 Effects of resveratrol (Res) and genistein (Gen) on the resting tension of phasic contraction in gastric smooth muscle strips. ^aP < 0.05, ^bP < 0.01 vs solvent control; n = 10.

Figure 3 Effects of phentolamine (Phe) and levorotatory-NG-nitroarginine (L-NNA) on phytoestrogen-induced suppression of the resting tension and basal mean amplitude of phasic contraction in gastric smooth muscle strips. ^aP < 0.05, ^bP < 0.01 vs corresponding resveratrol (Res) group; ^cP < 0.05, ^dP < 0.01 vs corresponding genistein (Gen) group.

Figure 4 Effects of glibenclamide (Gli), SQ22536 (SQ), ICI 182780 (ICI), and tamoxifen (Tam) on phytoestrogen-induced suppression of the resting tension and basal mean amplitude of phasic contraction in gastric smooth muscle strips. ^aP < 0.05, ^bP < 0.01 vs corresponding resveratrol (Res) group; ^cP < 0.05, ^dP < 0.01 vs corresponding genistein (Gen) group.

Figure 5 Effects of resveratrol (Res) and genistein (Gen) on CaCl₂ concentration-dependent contraction curves in gastric smooth muscle strips. n = 10.