Research Report
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 7, 2014; 20(41): 15319-15326
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15319
Figure 1
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Figure 1 Effects of diazoxide on serum activities. Aspartate aminotransferase (AST) (A) and alanine aminotransferase (ALT) (B) 4 and 24 h after hepatic reperfusion. Control group consisted of animals submitted to operative manipulation. Groups of animals submitted to liver ischemia/reperfusion were treated with normal saline (Saline group) or diazoxide (Diazoxide group) 15 min prior reperfusion. Data are expressed as mean ± SEM of 10 animals per group. a,cP < 0.05 vs Control group. CONTR: Control group; SAL: Saline group; DIAZ: Diazoxide group.
Figure 2
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Figure 2 Effects of diazoxide on liver mitochondrial oxidation and phosphorylation activities in liver ischemia/reperfusion. Control group consisted of animals submitted to operative manipulation. A: Respiratory control rate (RCR); B: State 3 respiration (S3); C: ADP/O ratio. Groups of animals submitted to liver ischemia/reperfusion were treated with normal saline (Saline group) or diazoxide (Diazoxide group) 15 min prior reperfusion. Data are expressed as mean ± SEM of 6 animals per group. aP < 0.05 vs Control group. CONTR: Control group; SAL: Saline group; DIAZ: Diazoxide group.
Figure 3
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Figure 3 Effects of diazoxide on serum levels of nitrite-nitrate in liver ischemia/reperfusion. Control group consisted of animals submitted to operative manipulation. Groups of animals submitted to liver ischemia/reperfusion were treated with normal saline (Saline group) or diazoxide (Diazoxide group) 15 min prior reperfusion. Data are expressed as mean ± SEM of 10 animals per group. aP < 0.05 vs Control group. CONTR: Control group; SAL: Saline group; DIAZ: Diazoxide group.
Figure 4
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Figure 4 Effects of diazoxide on systemic inflammation. Serum levels of tumor necrosis factor alpha (TNF-α) (A), interleukin-6 (IL-6) (B), IL-10 (C) and transforming growth factor β1 (TGF-β1) (D) in liver ischemia/reperfusion. Control group consisted of animals submitted to operative manipulation. Groups of animals submitted to liver ischemia/reperfusion were treated with normal saline (Saline group) or diazoxide (Diazoxide group) 15 min prior reperfusion. Data are expressed as mean ± SEM of 6 animals per group. aP < 0.05 vs Control group. CONTR: Control group; SAL: Saline group; DIAZ: Diazoxide group.