Combination of chemotherapy and immunotherapy for colon cancer in China: A meta-analysis

Figure 1 Flow diagram showing record identification, screening and study inclusion process.

Figure 2 Overall survival. A: Comparison of 1-, 2- and 3-year overall survival (OS) between the chemo-dendritic cell-cytokine-induced killer cells and chemo-alone groups. The fixed-effects meta-analysis model (Mantel-Haenszel method) was used. Each trial is represented by a square, the center of which gives the odds ratio for that trial. The size of the square is proportional to the information in that trial. The ends of the horizontal bars denote a 95%CI. The black diamond gives the overall odds ratio for the combined results of all trials; B: Mean survival including two trials (Wei et al[22] and Ying et al[23]) with excel line graph. The dotted line represents the trend line of each group.

Figure 3 Disease-free survival. A: Forest plot for disease-free survival (DFS). The fixed effects model (Mantel-Haenszel method) was used in this analysis; B: Mean DFS including two trials (Wei et al[22] and Ying et al[23]) with excel line graph. The dotted line represents the trend line of each group.

Figure 4 Comparison of objective response rate and disease control rate following treatment with chemo-dendritic cell-cytokine-induced killer cells and chemo-alone. The fixed effects meta-analysis model (Mantel-Haenszel method) was used in this analysis. ORR: Objective response rate; DCR: Disease control rate.

Figure 5 Forest plot of immunophenotype assessment. Data from patients after chemo-dendritic cell-cytokine-induced killer cell treatment and chemo-alone treatment. The random effects meta-analysis model (Mantel-Haenszel method) was used in this analysis.