Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers

Figure 1 Androgen receptor signaling in hepatocellular carcinoma (A) and pancreatic cancers (B). ADAM10: A disintegrin and metalloprotease 10; AHR: Aryl hydrocarbon (or dioxin) receptor; AR: Androgen receptor; ARE: Androgen responsive element; ARNT: AHR nuclear translocator; DHT: 5-alpha-dihydrotestosterone; Foxa1/2: Vertebrae forkhead box A 1/2; GRP78/BiP: Glucose-regulated protein 78; GSK-3beta: Glycogen synthase kinase-3beta; HBV: Hepatitis B virus; HCV: Hepatitis C virus; MICA/B: Major histocompatibility complex class I chain-related gene A/B; MMP-9: Matrix metalloprotease 9; STAT3: Signal transducer and activator of transcription 3; TGF beta-1: Transforming growth factor beta-1; VEGF: Vascular endothelial growth factor.