Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity

Figure 1 MicroRNAs expression in hepatoma cells HepG2. 2.15 and HepG2. A: Scatter plots of 1008 miRNAs indicate 2^-dCT numerical values in HepG2 cells (x-axis) and HepG2.2.15 cells (y-axis). The black line indicates fold changes of 1. The pink lines indicate 5-fold change in miRNA expression threshold, comparing HepG2.2.15 with HepG2. Red + indicates miRNA expressed at least 5-fold higher in HepG2.2.15 than in HepG2 cells. Green + indicates miRNA expressed at least 5-fold lower in HepG2.2.15 than in HepG2 cells. Black + indicates that the difference of miRNA between the two cells was within 5-fold; B: Comparison of miRNAs expression between HepG2 and HepG2.2.15 cells. Red color indicates miRNA expressed at least 5-fold higher in HepG2.2.15 than in HepG2 cells. Green color indicates miRNA expressed at least 5-fold lower in HepG2.2.15 than in HepG2 cells. miRNAs: MicroRNAs.

Figure 2 MicroRNAs expressed at more than 5-fold difference between hepatoma cells. HepG2.2.15 and HepG2 cells. A: MiRNA expressed at least 5-fold higher in HepG2.2.15 than in HepG2 cells; B: MiRNA expressed at least 5-fold lower in HepG2.2.15 than in HepG2 cells. miRNAs: MicroRNAs.

Figure 3 MicroRNAs and Toll-like receptor signaling pathway in hepatitis B virus infection. IRAK: Interleukin (IL)-1 receptor-associated kinase 1; IRF: Interferon regulator factor; miRNA: MicroRNA; MYD88: Myeloid differentiation factor 88; NF-κB: Nuclear factor-κB; TLR: Toll-like receptor; TRAF: Tumor necrosis factor receptor-associated factor.