Potential role of human papilloma virus in the pathogenesis of gastric cancer

Figure 1 Representative subset of quantitative polymerase chain reaction amplification plots for 55 patients including non-informative cases. A: Human papilloma virus (HPV) type 16; B: HPV type 18; C: One or more subtypes from the group of 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68; D: Internal control (β-globin). The two leftmost curves correspond to the positive controls, horizontal line corresponds to ΔRn threshold. ΔRn: The magnitude of the generated fluorescent signal.

Figure 2 Representative results of immunostaining for p16INK4a protein. A: Negative immunostaining in gastric adenocarcinoma G3; B: Human papilloma virus-positive squamous cell carcinoma of the oropharynx as the positive control. Scale bar: 200 μm.