Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats

doi:10.3748/wjg.v20.i16.4753

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Apr 28, 2014 (publication date) through Nov 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2014; 20(16): 4753-4760
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4753

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Figure 1 Liver morphology. A: Normal group; B: CCl₄-treated group; C: Positive-drug + CCl₄; D: 6 g/kg CIE + CCl₄; E: 18 g/kg CIE + CCl₄; F: 54 g/kg CIE + CCl₄. CIE: Cichorium intybus L. extract.

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Figure 2 Hematoxylin-eosin (original magnification × 100) of liver sections in rats. A: Normal group; B: CCl₄-treated group; C: Positive-drug + CCl₄; D: 6 g/kg CIE + CCl₄; E: 18 g/kg CIE + CCl₄; F: 54 g/kg CIE + CCl₄. CIE: Cichorium intybus L. extract.

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Figure 3 Masson Trichrome examinations (original magnification × 40) of liver sections in rats. A: Normal group; B: CCl₄-treated group; C: Positive-drug + CCl₄; D): 6 g/kg CIE + CCl₄; E: 18 g/kg CIE + CCl₄; F: 54 g/kg CIE + CCl₄. CIE: Cichorium intybus L. extract.

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Figure 4 Immunohistochemical examination of transforming growth factor-β1 positive cells (original magnification × 200) of liver sections in rats. A: Normal group; B: CCl₄-treated group; C: Positive-drug + CCl₄; D: 6 g/kg CIE + CCl₄; E: 18 g/kg CIE + CCl₄; F: 54 g/kg CIE + CCl₄. CIE: Cichorium intybus L. extract.

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Figure 5 Immunohistochemical examination of α-smooth muscle actin positive cells (original magnification × 200) of liver sections in rats. A: Normal group; B: CCl₄-treated group; C: Positive-drug + CCl₄; D: 6 g/kg CIE + CCl₄; E: 18 g/kg CIE + CCl₄; F: 54 g/kg CIE + CCl₄. CIE: Cichorium intybus L. extract.

Citation: Li GY, Gao HY, Huang J, Lu J, Gu JK, Wang JH. Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats. World J Gastroenterol 2014; 20(16): 4753-4760
URL: https://www.wjgnet.com/1007-9327/full/v20/i16/4753.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i16.4753