Beyond white light endoscopy: The role of optical biopsy in inflammatory bowel disease

Figure 1 Endocytoscopic image at magnification × 1390 showing one single colonic crypt. Goblet and epithelial cells are clearly evident.

Figure 2 Endoscope-based confocal laser endomicroscopy of Crohn’s disease shows remarkable cell infiltration, disturbed colonic architecture and leakage indicating severe inflammation.

Figure 3 Probe-based confocal laser endomicroscopy in patient with Crohn’s disease without histologic activity. Colonic crypts are regularly arranged with normal shape and size. Micro-vessels within the lamina propria are easily visible. Bar = 20 μm.

Figure 4 Probe-based confocal laser endomicroscopy images of (A) normal colonic mucosa; B: Adenomatous polyp with low grade dysplasia. Bar = 20 mm; and C: The corresponding histologic image for the adenomatous polyp with dysplasia (magnification × 40).