Magnifying chromoendoscopy combined with immunohistochemical staining for early diagnosis of gastric cancer

Figure 1 Magnifying chromoendoscopic findings. A: Type E pits; B: Type E pits after dye staining; C: Type F pits; D: Type F pits after dye staining, arrows show disorderly arranged thickened capillaries. Magnification, ×100. Type E: Villous pits, with finger-like tubers similar to enteral villus-like changes; Type F: The pits have obscure or disappearing structures and extremely irregular arrangement.

Figure 2 Immunohistochemical results. A: Expression of p53 in gastric pits in chronic atrophic gastritis, and nuclei were stained dark brown; B: p53 expression was undetectable in gastric pits in chronic superficial gastritis; C: Expression of proliferating cell nuclear antigen (PCNA) was detected in gastric pits in chronic atrophic gastritis, and nuclei were stained dark brown; D: PCNA expression was undetectable in gastric pits in chronic superficial gastritis.