Overexpression of carbonic anhydrase II and Ki-67 proteins in prognosis of gastrointestinal stromal tumors

Figure 1 The scale is 5 μm using a × 400 objective as recommended. Carbonic anhydrase II (CA II) and Ki-67 proteins expressed in gastrointestinal stromal tumors (GISTs) and other malignant tumors. A: Hematoxylin and eosin in GISTs; B: CA II positive protein in the GISTs; C: CA II and Ki-67 negative protein in GISTs; D: Ki-67 positive protein in the GISTs; E: CAII positive protein in neural astrocytoma; F: CA II positive protein in schwannoma; G: CA II positive protein in leiomyoma of the stomach; H: CA II positive protein in malignant solitary fibrous tumor.

Figure 2 Analysis of survival rates (Kaplan-Meier) and comparison of survival rates in gastrointestinal stromal tumors groups (log-rank test). A: The highest survival rate was found in those patients that received complete tumor resection and postoperatively took imatinib (400 mg/d), while in those patients not receiving complete tumor resection and postoperative imatinib, the survival rate was lowest (log-rank P = 0.000). 1: Resected completely with imatinib administrated postoperatively, 2: Resected completely without imatinib administrated postoperatively, 3: Resected incompletely with imatinib administrated postoperatively, 4: Resected incompletely without imatinib administrated postoperatively; B: The survival rates in carbonic anhydrase (CA) II-positive group were significantly higher than those in negative groups (CA II, log-rank P = 0.000); C: The survival rates in Ki-67-positive group were higher than those in negative groups (Ki-67, log-rank P = 0.004); D: The survival rates in CD117-positive group were significantly higher than those in negative groups (CD117, log-rank P = 0.000); E: The higher survival rates were found in those patients that received complete tumor resection (R0) (R0, log-rank P = 0.000); F: The higher survival rates were found in those patients with National Institutes of Health (NIH) high risk (NIH risk, log-rank P = 0.006).

Figure 3 Carbonic anhydrase II positive cases in gastrointestinal stromal tumors according to National Institutes of Health risk grade. There were five cases with extremely low risk, 15 with low risk, 16 with medium risk, and 77 with high risk. Carbonic anhydrase (CA) II expressed in 113 gastrointestinal stromal tumors: “0” represents the negative cases, and “1” the positive cases. NIH: National Institutes of Health.