Curcumin attenuated paracetamol overdose induced hepatitis

Figure 1 Effects of curcumin on serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, hepatic glutathione, hepatic malondialdehyde, interleukin-12, interleukin-18 in mice with paracetamol overdose. A: Serum glutamic oxaloacetic transaminase (SGOT); B: Serum glutamic pyruvic transaminase (SGPT); C: Hepatic glutathione (GSH); D: Hepatic malondialdehyde (MDA); E: Interleukin (IL)-12; F: IL-18. ^bP < 0.01 vs control group; ^dP < 0.01 vs N-acetyl-P-aminophenol (APAP) group; ^eP < 0.05 vs APAP + curcumin (CUR) 200 group. 1: Control; 2: APAP; 3: APAP + CUR 200; 4: APAP + CUR 600.

Figure 2 Effects of curcumin improved liver histopathology (hematoxylin and eosin stain, ×10). A: Control group showed normal; B: N-acetyl-P-aminophenol (APAP) group showed extensive hemorrhagic hepatic necrosis at all zones; C: APAP + curcumin (CUR) 200 group showed mild focal necrosis and hepatic lobule was preserved; D: APAP + CUR 600 group showed the hepatic lobule was preserved with limited hepatic change. Arrows indicate hepatic necrosis, CV indicate central vein, and PT indicate portal system.