Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?

Figure 1 Immunohistochemical staining of neuronal precursor cell-expressed developmentally down-regulated 4-1 and phosphatase and tensin homolog protein in different histological samples of gastric tissues. A: The expression of neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) in normal gastric mucosa (NGM); B: The expression of NEDD4-1 in chronic gastritis (CG); C: The expression of NEDD4-1 in intestinal metaplasia (IM); D: The expression of NEDD4-1 in dysplasia (Dys); E: The expression of NEDD4-1 in gastric carcinoma (GC); F: The expression of phosphatase and tensin homolog (PTEN) in NGM; G: The expression of PTEN in CG; H: The expression of PTEN in IM; I: The expression of PTEN in Dys; J: The expression of PTEN in GC. Magnification: × 200.

Figure 2 Relative neuronal precursor cell-expressed developmentally down-regulated 4-1 and phosphatase and tensin homolog protein expression level in gastric carcinoma compared to adjacent non-tumorous mucosa. Immunoblots of neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1), phosphatase and tensin homolog (PTEN) were scanned and the relative protein expression level of tumor samples vs their non-cancerous counterparts is expressed as % of β-actin. ^aP < 0.05.