Physiological and pathological role of local and immigrating colonic stem cells

Figure 1 Possible origin of the colonic mesenchymal and epithelial cells. Arrows represents possible stem cell origin and routes for derivation of colonic mesenchymal and epithelial cells. MET: Mesenchymal-to-epithelial transition; EMT: Epithelial-to-mesenchymal transition.

Figure 2 CD45^–/cytokeratin⁺ epithelial cells (green cytoplasmic immunoreaction) containing Y chromosomes (green nuclear dots; white arrows) in the germinative zone of a colonic crypt are well differentiating from the CD45⁺ intraepithelial lymphocyte (red arrow) (cytokeratin-fluorescein isothiocyanate; CD45-rhodamine; Y-chromosome fluorescence in situ hybridization in a biopsy sample of male bone marrow recipient female patient with moderate non-specific colitis; 100 × magnification).