Cell sheet technology for regeneration of esophageal mucosa

Figure 1 Transplantable oral mucosal epithelial cell sheet. A: Swine buccal oral mucosal tissue taken by punch biopsy; B: Human oral mucosal epithelial cell sheet harvested from temperature-responsive cell culture insert; C: Cultured human oral mucosal epithelial cells just become confluent on the surface of temperature responsive culture insert; D: The oral mucosal epithelial cells cultured for more than 5 d.

Figure 2 Transplantation of oral mucosal epithelial cell sheets on esophageal ulcer surface in animal model. A: Swine esophageal ulcer after endoscopic mucosal resection (EMR); B: Swine oral mucosal epithelial cell sheet transplanted on esophageal ulcer after EMR; C: Swine esophageal ulcer after endoscopic submucosal dissection (ESD); D: Two swine oral mucosal epithelial cell sheets transplanted on esophageal ulcer after ESD.