Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors

Figure 1 Results of sucrose permeability studies showing a significant difference in sucrose leak in patients with Barrett’s esophagus (and taking proton pump inhibitors) compared to healthy controls. Data represents the mean ± SE. P < 0.003 (Student’s t test). SE: Standard error.

Figure 2 Sucrose leak among Barrett’s esophagus patients after discontinuation of proton pump inhibitors for 7 d. Data represents the mean ± SE. P = 0.28 (n = 38). SE: Standard error; PPI: Proton pump inhibitor.

Figure 3 Proton pump inhibitor-induced transepithelial leak as a function of time. A: Scatter plot illustrating a decrease in sucrose leak in reflux disease patients on proton pump inhibitors (PPIs) over time with each data point representing the sucrose leak of one patient (n = 41); B: Statistically significant decrease in sucrose leak between patients on PPIs for < 3 mo vs 3 mo to 25 years. Data represents the mean ± SE. P = 0.003. SE: Standard error.