Combined inhibitors of angiogenesis and histone deacetylase: Efficacy in rat hepatoma

doi:10.3748/wjg.v17.i31.3623

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Aug 21, 2011 (publication date) through Nov 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2011; 17(31): 3623-3629
Published online Aug 21, 2011. doi: 10.3748/wjg.v17.i31.3623

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Figure 1 Macroscopic tumor growth. The results are given as absolute values. ^aP = 0.025, MS-275 vs control 1; ^bP = 0.005, ZK/PTK/MS vs control 1. PTK/ZK: PTK787/ZK222584 (Vatalanib^®); TAM: Tamoxifen; cRA: 9-cis-retinoic acid.

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Figure 2 Macroscopic tumor growth and TdT-mediated dUTP-biotin nick end labeling assay. A: Control 1, large tumor volume. B: PTK787/ZK222584 (PTK/ZK) + MS-275, small tumor volume. C: Control 1, (mediated dUTP-biotin nick end labeling) TUNEL assay for apoptotic cells (dark brown). D: PTK/ZK + MS-275: TUNEL assay for apoptotic cells (dark brown).

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Figure 3 Hematoxylin-eosin and proliferating cell nuclear antigen staining. A: Control 1, hematoxylin-eosin staining. B: Quadruple therapy, disintegrating cells, necrosis. C: Control 1, proliferating cell nuclear antigen (PCNA) staining for proliferating cells. D: Quadruple therapy, PCNA staining, reduced number of cells, and large necrotic area.

Citation: Ganslmayer M, Zimmermann A, Zopf S, Herold C. Combined inhibitors of angiogenesis and histone deacetylase: Efficacy in rat hepatoma. World J Gastroenterol 2011; 17(31): 3623-3629
URL: https://www.wjgnet.com/1007-9327/full/v17/i31/3623.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i31.3623