Diagnosis of gastric epithelial neoplasia: Dilemma for Korean pathologists

Figure 1 Consensus diagnosis of tubular adenoma with low grade dysplasia. A: Regular distribution of small proliferative glands without budding or branching (HE, × 100); B: Elongated nuclei with stratification below half of the cytoplasm (HE, × 200).

Figure 2 Major consensus diagnosis of tubular adenoma with low-grade dysplasia. A: Regular distribution of small proliferative glands without budding or branching (HE, × 100); B: Ovoid and vesicular nuclei with conspicuous nucleoli and nuclear stratification not exceeding basal half of the cell (HE, × 400).

Figure 3 Consensus diagnosis of tubular adenoma with high-grade dysplasia. A: Compact small glandular proliferation with some variation of gland size, budding and branching (HE, × 40); B: Elongated or oval nuclei with stratification above half of the cytoplasm in more than three contiguous glands (HE, × 200).

Figure 4 Major consensus diagnosis of tubular adenoma with high-grade dysplasia. A: Glandular crowding with some variation in gland size and budding (HE, × 100); B: Elongated or oval nuclei with stratification above basal half of the cytoplasm (HE, × 200).

Figure 5 Major diagnosis of tubular adenoma with high-grade dysplasia. A: Compact small glandular proliferation with variation in gland size, budding and branching (HE, × 100); B: Elongated or oval nuclei with stratification above basal half of the cytoplasm in more than three contiguous glands. Glandular complexity without definite invasion (HE, × 200).

Figure 6 Consensus diagnosis of adenocarcinoma. A: Compact small glandular proliferation without budding or branching. Relatively regular glandular distribution but enlarged, oval to round, and pleomorphic nuclei (HE, × 100); B: Another section showing villous configuration (HE, × 40); C: Hyperchromasia and mitoses with invasion into the lamina propria (arrow) (HE, × 400).

Figure 7 Major diagnosis after the consensus conference of adenocarcinoma. A: Compact small glandular proliferation with budding and branching. Regular glandular size and distribution (HE, × 100); B: Severe nuclear stratification approaching the top of the cytoplasm in more than three contiguous glands. Marked hyperchromasia and mitoses with invasion into the lamina propria (arrow) (HE, × 400).