Isolated lymphoid follicles in colon: Switch points between inflammation and colorectal cancer?

Figure 1 Intraepithelial male donor bone marrow origin CD45-/Y-FISH+ cell (white arrow) and CD45+/Y-FISH+ intraepithelial lymphocyte (red arrow) in the colonic biopsy specimen of a female acceptor. A: Chromosomal detection (green: Y-chromosome, red: X-chromosome; fluorescence in situ hybridization); B: CD45 and cytokeratin (green: cytokeratin, red: CD45; fluorescence immunohistochemistry; 130 × magnification).

Figure 2 3D reconstruction of a human colonic surgical sample (MIRAX Viewer, 3D, 3DHISTECH Ltd. , Budapest). A large subepithelial isolated lymphoid follicle (white star) can be seen. Colonic crypts (white arrow) with no connection to the luminal surface “outgrow” from the isolated lymphoid follicle.