From blood to gut: Direct secretion of cholesterol via transintestinal cholesterol efflux

Figure 1 Schematic overview of the reverse cholesterol transport pathways. ABCA1: Adenosine triphosphate (ATP)-binding cassette transporter A1; ABCG1: ATP-binding cassette transporter G1; ABCG5: ATP-binding cassette transporter G5; ABCG8: ATP-binding cassette transporter G8; SR-BI: Scavenger receptor class B type I; TICE: Transintestinal cholesterol efflux.

Figure 2 Enterocyte representation with a schematic overview of cholesterol transporters and potential transintestinal cholesterol efflux-related factors as discussed in this paper. PPARδ: Peroxisome proliferator-activated receptor δ; LXR: Liver X receptor; LDLR: Low density lipoprotein receptor; SR-BI: Scavenger receptor class B type I; ABCA1: Adenosine triphosphate (ATP)-binding cassette transporter A1; ABCG5: ATP-binding cassette transporter G5; ABCG8: ATP-binding cassette transporter G8; Hmgcr: 3-hydroxy-3-methyl-glutaryl-CoA reductase; Limp2: Lysosomal integral membrane protein 2; NPC1L1: Niemann-Pick C1-like 1 protein; TICE: Transintestinal cholesterol efflux.