Biliary cholesterol secretion: More than a simple ABC

Figure 1 Overview of hepatic cholesterol metabolism in relation to biliary sterol secrection. HDL: High-density lipoprotein; BA: Bile acid; LDLR: Low-density lipoprotein receptor; LRP: LDLR-related protein; NTCP: Na⁺ taurocholate co-transporting peptide; OATP: Organic anion transport polypeptides; SR-BI: Scavenger receptor class B type I; (V)LDL: (Very) low-density lipoprotein.

Figure 2 Overview of canalicular transporters/proteins that are involved in biliary bile acid, cholesterol and phospholipid secretion. ABC: ATP-binding cassette transporter; ATP8B1: ATPase class I type 8B member 1; SR-BI: Scavenger receptor class B type I; NPC1L1: Niemann-Pick C1-like protein 1.