Brain activity following esophageal acid infusion using positron emission tomography

Figure 1 This schema illustrates the procedure of esophageal infusion and brain positron emission tomography scanning. The infusions were performed twice for pH 1 and 7 solutions (distilled water) and once for the pH 2 solution. In order to counterbalance the effects of the infusion order, the order was randomly selected per each subject from pH 1-7-2-7-1, pH 7-1-1-7-2 and pH 2-1-7-7-1 as shown. ¹First infusion; ²Second infusion; PET: Positron emission tomography.

Figure 2 Representative images from the subtraction analysis of the second pH 1 infusion minus the baseline. Left: Sagittal view; Right: Cranial view. A: Right parahippocampal gyrus (x: 28, y: -48, z: 2); B: Left superior temporal gyrus (temporal pole, BA38) (x: -52, y: 18, z: -26).

Figure 3 Representative images from the subtraction analysis of the second pH 1 infusion minus the first. Left: Sagittal view; Right: Cranial view. A: Right orbitofrontal cortex (x: 38, y: 36, z: -24); B: Right middle frontal gyrus (x: 22, y: 50, z: 8).