Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients

Figure 2 NR3C1 haplotypes predicted by PHASE in the cohort of 181 inflammatory bowel diseases patients. ¹Counter (a to y) for the 25 theoretically arising haplotypes in the inflammatory bowel diseases cohort. SNP: Single nucleotide polymorphism.

Figure 1 Most frequently occurring NR3C1 haplotypes and their single nucleotide polymorphisms composition. The localization of the variant nucleotides in the N3RC1 gene is indicated. All detected non-synonymous single nucleotide polymorphism (SNP) (R23K, A229T, N363S) flank the N-terminal transactivation domain. Only four out of 17 predicted haplotypes occur at a frequency higher than 2%.

Figure 3 Linkage disequilibrium calculations of single nucleotide polymorphisms in the NR3C1 gene. Linkage disequilibrium plot of r² values of observed variants in the N3RC1 gene. Colour scheme: r² = 0%, white, 0% < r² < 100%, shades of grey, r² = 100%, black.

Figure 4 Haplotype GR_2 and steroid therapy outcome. Odds ratios and confidence intervals for the number of GR_2 carriers vs wild-type carriers in the responder group compared with non-responders to glucocorticoid therapy. No significant associations were found. Statistical analysis was performed with Fisher’s exact test. OR: Odds ratio; CI: Confidence interval; CD: Crohn's disease; UC: Ulcerative colitis.

Figure 5 Haplotype GR_3 and steroid therapy outcome. Odds ratios and confidence intervals for the number of GR_3 carriers vs wild-type carriers in the responder group of responders compared with non-responders to glucocorticoid therapy. No significant associations were found. Statistical analysis was performed using Fisher’s exact test. CD: Crohn's disease; UC: Ulcerative colitis; NA: Not applicable.

Figure 6 NR3C1 variants and their influence on steroid therapy outcome. Odds ratios and confidence intervals for carriers of six single nucleotide polymorphisms against wild-type carriers in the group of glucocorticoid (GC) responders compared with GC non-responders. No significant associations were found. Statistical analysis was performed using chi-square or Fisher’s exact test.