Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis

Figure 1 Characterization of circulating progenitor cell populations by flow cytometry. A: Forward/sideward scatter analysis; B: Isotype controls; Representative two-color flow cytometry analysis of the peripheral blood mononuclear cell (MNC) fraction, demonstrating CD133⁺ (C and D), c-kit⁺ (E), and Bcrp-1⁺ (F) populations.

Figure 2 Significant correlations. Correlation of numbers of circulating CD133⁺ cells with patient age (A). Correlation of the numbers of circulating CD133⁺CD34^- cells with the numbers of circulating Bcrp-1⁺/CD34^- cells (B) and with stromal cell-derived factor-1 (SDF-1) plasma levels (C).

Figure 3 Coexpression of CXC chemokine receptor 4 (CXCR4), the receptor for SDF-1, on circulating CD133⁺ cells and c-kit⁺ cells as revealed by flow cytometry.