UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer

Figure 1 Electropherograms/gene scanning: Example results of TA promoter region of the UGT1A1 gene. A: Control heterozygous genotype (6/7); B: Patient homozygous genotype (6/6); C: Patient homozygous genotype (7/7); D: Negative control.

Figure 2 Time to progression and UGT1A1 status. WT (6/6) 8.1 mo (range = 5.7-10.5) vs (6/7, 7/7) 8.2 mo (range = 6.3-9.4), P > 0.05; WT: Solid line, (6/7, 7/7): Dashed line.

Figure 3 Overall survival and UGT1A1 status. WT (6/6) 21.2 mo (range = 12.3-41.0) vs (6/7, 7/7) 18.9 mo (range = 16.4-34.1), P > 0.05; WT: Solid line, (6/7, 7/7): Dashed line.