Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer

Figure 1 Liver necropsy stained with antibody against hepatitis B core antigen. FCH is also characterized by massive expression of hepatitis B core antigen (nuclear and cytoplasmic).

Figure 2 Liver necropsy. A: Stained with Mason trichromic; B: Stained with eosin-hematoxylin. FCH is characterized by marked hepatocellular swelling, lobular disarray and cholestasis, with only mild or no portal or lobular inflammation, combined with acute cholangiolitis and fibrosis surrounding the cholangioles.