Hirschsprung’s disease: Is there a relationship between mast cells and nerve fibers?

Figure 1 Perineural and intraneural mast cells (× 200) are increased in HD patients (A) compared to non-HD patients (B). (Toluidine blue, × 200).

Figure 2 Increased number of mast cells in perivascular distribution (× 400) in HD case (A) as compared to non-HD case (B) showing an occasional mast cell (× 400) only. (Toluidine blue).

Figure 3 Hypertro-phic nerve fibers in submucosa (× 100) in HD case (A) as compared to small and thin nerve fibers (black arrows, × 100) in non-HD case (B). (S-100).

Figure 4 Hypertrophic nerve fiber in submucosa surrounded by mast cells. (S-100, × 400).