Proteasome inhibitor ameliorates severe acute pancreatitis and associated lung injury of rats

Figure 1 Effect of MG-132 on serum amylase level (A), pancreatic TNF-α level (B), lung water content (C), pancreas/body weight ratio (D), and MPO activity in pancreas (E) and lung (F). Write bars represent the control group (a sham operation consisting of laparotomy and punctrue of the duodenum), black bars represent the SAP group (with retrograde injection of sodium taurocholate into pancreatic duct) and grey bars represent the MG-132 group (10 mg/kg MG-132 ip 30 min before the induction of pancreatitis). ^aP < 0.05 vs sham group, ^cP < 0.05 vs SAP group.

Figure 2 Representative images illustrating histologically observed morphology of pancreas in pulmonary sections (HE, × 200).