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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 7, 2007; 13(37): 5021-5024
Published online Oct 7, 2007. doi: 10.3748/wjg.v13.i37.5021
Published online Oct 7, 2007. doi: 10.3748/wjg.v13.i37.5021
Figure 1 Missense germline mutation of exon 6 of MSH6 gene in the proband of H14 HNPCC kindreds.
Arrow indicates the mutation site, The single basyl substitution was transversed from A to T (A>T) at the codon 1163, the codon from GAA to GTA, causing the amiod acid changes from glutamine to valine, the change was identified as a new SNP. A and B represent the forward sequence and reverse, respectively.
Figure 2 Missense germline mutation of exon 4.
6 of MSH6 gene in the proband of H40 HNPCC kindreds. Arrow indicates the mutation site, The single basyl substitution was transvered from T to C (T>C) at the codon 666, the codon from TCT to CCT, causing the amiod acid changes from serine to proline. A and B represent the forward and reverse sequence, respectively.
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Citation: Yan SY, Zhou XY, Du X, Zhang TM, Lu YM, Cai SJ, Xu XL, Yu BH, Zhou HH, Shi DR. Three novel missense germline mutations in different exons of
MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families. World J Gastroenterol 2007; 13(37): 5021-5024 - URL: https://www.wjgnet.com/1007-9327/full/v13/i37/5021.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i37.5021