Molecular evolution of hepatitis A virus in a human diploid cell line

Figure 1 Summary of hotspots and time course of mutations in the process of consecutive passage of HAV in human cell line KMB17. The numbers on the curve indicate total mutations occurring at every 5 passages. Text in the boxes describes hot mutations occurring at the stage of cell culture passage.

Figure 2 Phylogenetic analysis of the complete VP1 region using MEGA software package version 3. 1. The numbers at nodes indicate bootstrap percentages after 1000 replications of bootstrap sampling. The bar indicates genetic distance.