Combined treatment of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates hepatic dysplastic nodule in a patient with liver cirrhosis

Figure 1 Enhanced computed-tomography (CT) scans in the arterial phase (A) and equilibrium phase (B) before administration of ACE-I in combination with VK. In the arterial phase, no obvious lesion could be detected whereas a low-density area (arrow) was noticed in the equilibrium phase.

Figure 2 Schema of clinical course. After administration of ACE-I and VK, the serum levels of both AFP and AFP-L3 gradually decreased. After one-year treatment, the serum levels of both AFP and AFP-L3 returned to the normal ranges. The arrows indicate the time points of CT examination before and after administration of this combined regimen.

Figure 3 Enhanced computed-tomography (CT) scans in the arterial phase (A) and equilibrium phase (B) after administration of ACE-I in combination with VK. After a 15-mo administration, the hepatic nodule disappeared in both the arterial phase and equilibrium phase.