In vitro study of lovastatin interactions with amiodarone and with carbon tetrachloride in isolated rat hepatocytes

Figure 1 Changes in the examined parameters (%) after 1 h incubation with different concentrations of lovastatin. The differences are expressed vs the control group.

Figure 2 Changes in the examined parameters (%) after 1 h incubation with 86 μmol/L CCl₄ and different concentrations of lovastatin. The differences are expressed vs the CCl₄ group.

Figure 3 Effect of lovastatin on CYP 2B1 protein expression in cultured rat hepatocytes. A: Western blot picture B: Expression of CYP2B1 (in %) Hepatocytes were incubated with 31 μmol/L lovastatin before western blotting analysis, as described in the methods part. Data are expressed as mean ± SD obtained from three independent experiments.