Osteoclast-like giant cell tumors of the pancreas and liver

Figure 1 Patient 1: Osteoclastic giant cell tumor of the liver: A: B-mode sonography (HDI 5000, Philips), contrast sonography during the B: arterial and C: portal phase (Siemens); D: resected tumor: cut surface shows distinct tumor areas with necrotic and hemorrhagic regions.

Figure 2 Histology (HE, x 20-40) of OGCT of the liver with a mixed cell population of osteoclastic giant cells and pleomorphic mononuclear cells (left), adenocarcinomatous component with mucinous inclusions (PAS, upper right) and squamous cell differentiation (middle).

Figure 3 Immunohistology of the OGCT of the liver. Panel A: mixed cell population of osteoclastic giant cells and pleomorphic mononuclear cells. CD68: histio-monocytic differentiation of osteoclastic giant cells, MIB 1: proliferation of mononuclear cells. Panel B: adenocarcinomatous component with mucinous inclusions: CK18+, CD68/vimentin: -.

Figure 4 Patient 2: osteoclastic giant cell tumor of the pancreas. A: B-mode (HDI 5000, Philips) and B: contrast sonography (Sonovue^®, low MI/CPS, Acuson Sequoia 512).

Figure 5 Histology (HE, x 20-40) of OGCT of the pancreas with a mixed cell population of osteoclastic giant cells and pleomorphic mononuclear cells (left) and myxoid tumor areas (right).