E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome

Figure 1 Immunohistochemical staining patterns. A: Primary tumor showing high E-cadherin membranous and cytoplasmic indices (MI = 1.75, CI = 0.85); B: Metastatic disease showing low E-cadherin indices (MI = 0.40, CI = 0.25); C: Metastatic disease in the liver showing high E-cadherin indices (MI = 1.00, CI = 0.60); D: Metastatic disease in the colon showing low E-cadherin indices (MI = 0.35, CI = 0.25).

Figure 2 Comparison of E-cadherin indices in primary tumors and metastases.

Figure 3 Comparison of E-cadherin indices and site of metastases.

Figure 4 Association of recurrence with E-cadherin CI indices in metastases.