Inhibitory effect of angiotensin II receptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis

Figure 1 Expression of HSCs in patients with NASH and NAFL (× 400). Liver sections were immunostained with both monoclonal anti-p75 antibody and monoclonal anti-α-SMA antibodies. Although most perisinusoidal HSCs were quiescent form (arrow heads) in NAFL, a number of arrow head were detected in the patient with NASH (arrow heads).

Figure 2 Significant decrease of activated and quiescent HSCs by 48-wk losartan treatment in a patient with NASH (double immunostaining with anti-p75 and α-SMA antibodies, × 200).

Figure 3 Average numbers of HSCs in five fields per slide at x200 magnification. A: number of activated HSCs; B: averaged ratio of activated HSCs to quiescent HSCs (Act-/Qui- Ratio: a ratio of activated HSCs to quiescent HSCs); C: averaged number of quiescent HSCs.