Pharmacokinetics and bioequivalence of ranitidine and bismuth derived from two compound preparations

Figure 1 Chromatograms of spiked plasma sample (B), plasma samples of patients before (A) and after (C) the administration of 200 mg ranitidine. M1 and M2 are metabolites of ranitidine.

Figure 2 Concentration-time curves of ranitidine in 20 Chinese volunteers after oral administration of two compound preparations. n = 20. Mean ± SD. Bars indicate standard deviations (lower bars for test drug and upper bars for reference drug).

Figure 3 Typical double-peak plasma profiles of ranitidine in two Chinese volunteers (№14 and №16) after oral administration of two compound preparations.

Figure 4 Concentration-time curves of bismuth in 20 Chinese volunteers after oral administration of two compound preparations. n = 20, mean ± SD. Bars indicate standard deviations (lower bars for test drug and upper bars for reference drug).