An inherent acceleratory effect of insulin on small intestinal transit and its pharmacological characterization in normal mice

Figure 1 Experimental design carried out to explore various systems/mechanisms involved in insulin-induced acceleration of small intestinal transit in normal mice.

Figure 2 Involvement of various mechanisms in insulin-induced acceleration of SIT in normal mice. Each value represents % acceleration of SIT. ^bP < 0.01 vs vehicle + vehicle-treated group [insulin (2 μU/kg); glibenclamide (10 mg/kg)] or % inhibition of SIT. ^bP < 0.01 vs vehicle + insulin-treated group (2 μU/kg) (data was derived from Table 2). Cloni (0.1): clonidine (0.1 mg/kg); Atrop (1): atropine (1 mg/kg); Verap (8): verapamil (8 mg/kg); Nalox (5): naloxone (5 mg/kg); Ondan (1): ondansetron (1 mg/kg).