Prognostic values of tumor endothelial markers in patients with colorectal cancer

Figure 1 RT-PCR analysis revealed over-expression of TEM-1, -7 and -7R in colorectal cancer (P = 0. 01, P = 0.04 and P = 0.03). TEM-8 over-expression in colorectal cancer was highly significant compared to normal colon (P = 0.001). No significant differences exist in the expression of TEM-2 and -6 between normal and cancer colorectal tissues.

Figure 2 Real-time quantitative RT-PCR. Shown in the figure are Mean copies/ng mRNA. Levels of expression of TEMs in colon tissues in tumors with different in different Dukes stages. The number of transcripts of TEM-1 is high in Dukes A and TEM-2 higher in Dukes B tumors. TEM-6 shows no difference in all three stages (Dukes A, B and C). Dukes C tumor expressed greatest level of TEM-8 (^aP = 0.001 vs Dukes A). Both TEM-7 and -7R shows higher level of expression in Dukes C, however the difference is not significant (P>0.05).