CpG oligodeoxynucleotides inhibit tumor growth and reverse the immunosuppression caused by the therapy with 5-fluorouracil in murine hepatoma

Figure 1 Tumor volumes (mean±SE) in BALB/c mice with hepatoma treated with sodium chloride (control, ◆, n = 5), non-CpG ODN (□, n = 5), CpG ODN (◇, n = 8), 5-FU (▲, n = 8) and 5-FU combined with CpG ODN (○, n = 8).

Figure 2 The serum levels of IL-12 and IFN-γ (mean±SE) in BALB/c mice with hepatoma after different treatments. Peripheral blood was collected from mice with tumor 24 h after the final injection of sodium chloride (control, n = 5), non-CpG ODN (n = 5), CpG ODN (n = 8), 5-FU (n = 8) and 5-FU combined with CpG ODN (n = 8). ODNs IL-12 and IFN-γ contents in sera were assayed with ELISA.