Hybrid artificial liver support system for treatment of severe liver failure

Figure 1 Schematic diagram of HALSS.

Figure 2 Morphology of hepatocytes. A: freshly isolated single hepatocytes stained with trypan blue (×200); B: spheroid formation after 24 h of spheroid culture (×100).

Figure 3 Spheroid cultivation of hepatocytes at a density of 5×10⁶/mL cells. Control hepatocytes were cultivated in a petri dish at the same density. A: albumin production; B: urea synthesis.

Figure 4 Changes of total bilirubin, ALT, albumin and PTA index in patients in HALSS group, Plasmapheresis group and control group. Pre-: index before treatment. Post-: index at two weeks after treatment.