Loss of heterozygosity: An independent prognostic factor of colorectal cancer

Figure 1 LOH at three genetic loci in a 52-yr-old male with stage IV disease (A) and MSI at two genetic loci in a 47-yr-old male with stage II disease (B) shown as representative results of GeneScan. A: LOH at three genetic loci in a 52-yr-old male with stage IV disease; B: MSI at two genetic loci in a 47-yr-old male with stage II disease. ¹Size of the PCR product (in bp). ²Fluorescence intensity of peak. 3Homozygosity. The arrowhead indicated novel alleles.

Figure 2 The number and percentage of LOH. Panel A: The number of LOH; Panel; B: The percentage of LOH.

Figure 3 Comparison of the clinicopathological factors with 3-yr survival in colorectal cancer patients. ─ : Low LOH group;-----: High LOH group.