Pyrrolidine dithiocarbamate reduces ischemia-reperfusion injury of the small intestine

Figure 1 Intestinal microvascular perfusion in (% of baseline) during 30 min of ischemia and 2 h of reperfusion measured by L-DF. Values are expressed as mean±SE of six animals in each group (^aP<0.05 vs IR). B: Baseline.

Figure 2 Ileal HO activity in all three experimental groups at the end of 2 h of reperfusion (^bP<0. 01 vs IR).

Figure 3 Serum LDH levels (U/L) at the end of 2 h reperfusion period. Values are expressed as mean±SE of six animals in each group. In PDTC group, LDH was significantly lower compared to the IR group (^bP<0.001 vs IR).

Figure 4 Comparison of histological scores of ileal mucosa between three experimental groups (^bP<0. 01 vs IR).

Figure 5 Representative photomicrographs of histological sections of ileum (a) in sham operated animals, (b) subjected to 30-min period of ischemia and 2-h period of reperfusion (IR) and (c) subjected to PDTC+IR (H&E, original magnification ×100).