Etiology and functional status of liver cirrhosis by 31P MR spectroscopy

Figure 1 MR images of a healthy volunteer in all orientations with selected matrix for spectroscopic measurement and indicated volume of interest for spectra evaluation.

Figure 2 ³¹P MR spectra of the liver in a healthy volunteer (A) and in a patient with liver cirrhosis (B). PME - phosphomonoesters; Pi - inorganic phosphate; PDE - phosphodiesters; γATP, αATP, βATP - γ, α and β phosphates of adenosine triphosphate.

Figure 3 Results of principal component analysis (CPS). Individual positions of spectra displayed on the PCA scatterplots. Principal components are standardized (centered and scaled to unit variance). Principal component 1 explains 47 % of total variance, principal component explains 3 16% of total variance. (A) Patients with only alcoholic etiology and controls; (B) patients with only viral etiology and controls. Child-Pugh score subgroups (A, B, and C) and controls are bounded. (C) Projection of the principal component loadings on the planes 1 and 3.

Figure 4 Results of principal component analysis (etiology). (A) Individual positions of spectra of patients with CPS-B and C together with a control group are displayed on the PCA plot. Etiological groups (alcoholic, viral and cholestatic) and controls are bounded. Principal component 1 explains 46 % of total variance, principal component 3 explains 17% of total variance; (B) Projection of the principal component loadings on the planes 1 and 3.